 |
08-05-2007, 04:59 PM
|
#1
|
|
Senior Member
Join Date: Mar 2006
Posts: 4,780
|
HERA two-year Herceptin arm results--the bad news and the good news!:
Was listening to Martine Piccart (head of the HERA trial) interviewed on Breast Cancer Update volume 4 2007 (google it).
She believes there may not even be results in 2008 and that even 2010 is "iffy" as it depends if they have enough "events" (recurrences and mets) to
report statistically significant results.
If they don't she said they may just report interim results in 2010 anyway as she feels everyone deserves to know at least what is known to date.
As that is the "bad News" --the GOOD NEWS is exactly the same ie, that they have SO FEW EVENTS ie, herceptin is so good at preventing recurrences!!! that they are unable yet decide if two years are better than one.
She stated that she is only sorry she didn't have another arm for three months of treatment or so.
There are other fascinating interviews in this edition of BCU--listen up!
|
|
|
|
08-06-2007, 06:41 AM
|
#2
|
|
Senior Member
Join Date: Aug 2006
Posts: 3,380
|
Here is the Link
|
|
|
|
|
08-06-2007, 07:33 AM
|
#3
|
|
Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
|
Dr. Winer (at SABCS) indicated that the reason they keep stretching out the 2 years of Herceptin results is because there is no difference between the one year of Herceptin and the two years of Herceptin. It has nothing to do with lack of recurrences. If there were very little recurrences, they would say right away (much like the 50% reduction in recurrences for the 1 year of Herceptin). They would want everyone to know so they could continue those on it asap and maybe start others for another year.
The trial coordinators are hoping that as time passes, one will see that 2 years is more effective over time with less recurrences overall. This would be much the same as the original Tamoxifen studies where initially, 2 yrs wasn't any better than taking Tamoxifen for 5 yrs but over time, 5 yrs was much, much more beneficial.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
|
|
|
|
|
08-06-2007, 10:09 AM
|
#4
|
|
Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
|
Becky is completly right in that there is no significant difference in one vs two years Herceptin. Currently there is a clincial trial on six months of Herceptin. They know that the Herceptin works, they just don't know whether more is better or less is better. One of these days they will determine just how much Herceptin is needed to do the trick. At any rate, we HER2ers should be happy that we have Herceptin.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
|
|
|
|
|
08-06-2007, 12:07 PM
|
#5
|
|
Guest
|
Reading Hopeful's link!
Hopeful's link to other articles was very helpful. I read most of the articles and learned much that I was not aware of previously. I recommend this link to anyone interested in knowing more about HER2+ disease and her/his likelihood of recurrence. I found the news encouraging.
|
|
|
|
|
08-07-2007, 02:07 AM
|
#6
|
|
Senior Member
Join Date: Jan 2007
Location: Adelaide, South Australia, Australia
Posts: 144
|
Thank You Lani!
Thank you for being our guardian researcher...This is indeed mixed news, but I tink the good news prevails! Belindaxxxx
__________________
Belinda
- Diagnosed 3 Jan 2007, Stage IIb, Mastectomy and axillary clearance 10 Jan 07, 6 of 19 nodes affected, multi-focal cancer, HER2 positive. Second mastectomy (prophylactic). Chemo - AC 3 months, Taxol 3 months - then radiation 5 weeks.
- Aug 2011 - Diagnosed with Stage IV mets to lung, sternum and 12 or so thoracic nodes - Rads to Sternum, then weekly abraxane and herceptin for 12 weeks.
- May 2012- good scans - all nodes still about normal size, hole in sternum repairing, lung tumour 'obliterated'.
Ongoing herceptin every 3 weeks. Bloods still all good! Life good!
- March 2013 - recurrence - tumours in lungs and mediastinum (coughing up blood) - immediate radiation treatment to right lung and mediastinum, still on Herceptin, and 3 months of Vinoralbine - stable for a little while!
- Coughing and breathlessness started again September 2013, treated as radiation-induced fibrosis (which can be seen on scans - albeit stable). ie puffers, steroids
- January 2014 - cough becomes bloody again, scans show big mediastinal tumour wrapped around and choking the life out of my right main bronchus, radiation deemed off limits as my lungs are hypersensitive to radiation (measured by existing damage from 2013) .....................- ie I am in the 5% of people likely to suffer severe radiation damage to the lungs that they warn you about before starting treatment! (so special! :) )
- Started chemo Feb 2014 - continuing Herceptin (continuous since Aug 2011), with Carboplatin and Gemcitabine. Discontinued Gemcitabine because of se's. Starting cycle 5 Herc/Carbo 5 May 2014.
- Meantime.....coughing and breathlessness increased to SCARY levels with racing heartbeat that won't slow down, breath that won't come back, even just walking to the bathroom or up 3 or 4 steps.
- ICU from May 5 2014, collapsed right lung due to tumour, small pulmonary embolism (left), tumours growing in mediastinum left and right, dvt lower right leg
- Plan seems to be bronchoscope next week to see if tumour can be lasered and stent inserted in right bronchus to reopen air access to lower parts of right lung. If that is successful might be able to have brachytherapy to worst tumour, otherwise no more options for external radiotherapy.
|
|
|
|
|
08-06-2007, 11:13 AM
|
#7
|
|
Senior Member
Join Date: May 2006
Location: California
Posts: 668
|
I have a question, Lani
Are you a bc survivor?...You do not have information in your profile, so I was just wondering... Thanks.
__________________
1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.
2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.
2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
|
|
|
|
| Thread Tools |
|
|
| Display Modes |
 Hybrid Mode
|
Posting Rules
|
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
HTML code is Off
|
|
|
All times are GMT -7. The time now is 09:28 AM.
|
