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it's amazing--breast cancer cells fuse with stromal cells (human-mouse hybrid)
It is amazing it has taken so long to discover this science-fiction like ability of cancer cells!
ABSTRACT: Spontaneous Fusion with, and Transformation of Mouse Stroma by, Malignant Human Breast Cancer Epithelium [Cancer Research; Subscribe]
Adenocarcinoma cells from the pleural effusion of a patient with breast cancer were injected into the mammary glands of nude mice and grown into solid tumors. A cell line derived from these tumors expressed ?-smooth muscle actin but not human cytokeratin 7, indicating "activated" stroma of mouse origin. Cells in mitosis exhibited mainly polyploid mouse karyotypes, but 30% had mixed mouse and human chromosomes, among which 8% carried mouse/human translocations. Nuclei of interphase cells were 64% hybrid. Hybrid mouse/human nuclei were also detected in the primary xenograft. Thus, synkaryons formed in the solid tumor by spontaneous fusion between the malignant human epithelium and the surrounding normal host mouse stroma. The transformed stroma-derived cells are tumorigenic with histopathologic features of malignancy, suggesting a new mechanism for tumor progression.
ALL THIS GOBBLYDGOOK TRANSLATES INTO THE FACT THAT THE HUMAN BREAST CANCER CELLS FUSED WITH THE MOUSE STROMAL CELLS LIKE A SPERM FUSES WITH AN EGG AND EXCHANGED NUCLEAR MATERIAL SO THAT THE CELLS HAD SOME CHROMOSOMES THAT WERE MOUSE AND SOME THAT WERE HUMAN AND SOME WHERE STRIPS OF THE DNA HAD COME FROM MOUSE AND SOME FROM HUMANS ON THE SAME CHROMOSOME!
Now to figure out how they do it--and what compounds prevent it!
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Hybrid Mode
