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07-31-2010, 01:59 PM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 4,780
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high blood levels of Coenzyme Q MAY be associated with higher risk of breast cancer
preliminary work--
Cancer Epidemiol Biomarkers Prev. 2010 Jul 28. [Epub ahead of print]
Plasma Coenzyme Q10 levels and Postmenopausal Breast Cancer Risk: The Multiethnic Cohort Study.
Chai W, Cooney RV, Franke AA, Shvetsov YB, Caberto C, Wilkens LR, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT.
1Epidemiology, Cancer Research Center of Hawaii.
Abstract
BACKGROUND: Coenzyme Q10 (CoQ10) is a component of the mitochondrial electron transport chain and is considered an important cellular antioxidant. Decreased circulating CoQ10 levels have been reported in women with breast cancer, but evidence is limited. We examined the association of plasma CoQ10 levels with postmenopausal breast cancer risk using prospectively collected blood samples.METHODS: Pre-diagnostic plasma levels of total CoQ10 were measured among 160 incident postmenopausal breast cancer cases and 289 controls in the Multiethnic Cohort Study. Cases and controls were individually-matched on age, sex, ethnicity, study location (Hawaii or California), hormone replacement therapy use, date/time of specimen collection and hours of fasting. Logistic regression was used to compute odds ratios and 95% confidence intervals. RESULTS: Plasma CoQ10 levels were positively associated with breast cancer risk, overall (P = 0.04). The association was stronger after women diagnosed within one year of blood draw were excluded to eliminate possible preclinical cases (odds ratio for the highest versus the lowest tertile, 2.26; 95% confidence interval, 1.22-4.19; P for trend, 0.01). CONCLUSIONS: Higher CoQ10 levels in postmenopausal women may be associated with increased breast cancer risk. Impact:A potential role for CoQ10 in the development and progression of breast cancer has been postulated, but epidemiological evidence is lacking. Findings from this prospective cohort study add to the limited literature, indicating the potential positive association of circulating CoQ10 with postmenopausal breast cancer risk.
PMID: 20668119
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07-31-2010, 02:08 PM
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#2
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Senior Member
Join Date: Dec 2008
Location: Southern Indiana
Posts: 455
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Re: high blood levels of Coenzyme Q MAY be associated with higher risk of breast canc
I take 400 units of CoQ10 a day. Should I rethink this? I may lower it to 200. Hummmmm.
__________________
Alice
04/08 age 50 III IBC Her2+++ ER/PR-8cm 14/14 Double M, Body and Brain CT/PET clear, ? on spine,Muga 53
06/08, 4 A/C, Neulasta
08/08, Herceptin/tax 12 every week
10/08, CT/PET clear, ? on pelvis, hips, MUGA 43, started Enalaprial for heart, Herceptin every 3 weeks
11/08 33Rads; 12/08 MUGA 48
2/09 MRI spine and bone scan, old mets to spine, Chest x-ray, blood work, IV NED,regular CPAP use,Zometa x6, first -flue like symptoms 2 days;Herceptin x3; stage 2 lymphoedema..sleeve and glove
4/09 Brain MRI - CLEAR; MUGA 54
7/09 chest ultrasound,
10/09 PET, brain and spin MRI NED Herceptin only. MUGA 59!!!
1/11 Hip replacement 7/11 Hip 2 replacement
4/12 4 years!! Herceptin
6/12 start reconstruction finish in 12/12
2/14 Herception - 6 years!!!
1 Corinthians 10:13 "No temptation has seized you except what is common to man. And God is faithful; he will not let you be tempted beyond what you can bear. But when you are tempted, he will also provide a way out so that you
can stand up under it."
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07-31-2010, 06:58 PM
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#3
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Senior Member
Join Date: Oct 2005
Posts: 823
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Re: high blood levels of Coenzyme Q MAY be associated with higher risk of breast canc
Well sheez, I have been taking CoQ10 200 mg a day for 5 yrs now. I started it with Onc approval when I started my Herceptin 5 yrs. ago, and have continued with it ever since even tho my treatment is done and over. Now I wonder if I need to stop?
__________________
Vicki
Texas
Biopsy Dx'd 3-23-05 Age 48
MRM 4-5-05 w/ 2 tumor's 5cm, and 6 cm (right side)
IDC (poorly differentiated infiltrating ductual carcinoma)
5+/16 nodes
Stage III A
Grade 3
ER/PR-, Her2/neu ++
Ki67 78%
Begin Chemo 5-2-05 4XAC Dose Dense , 4X Abraxane Dose Dense (ended August 05)
28 Rad's ended October 13 2005
Started Herceptin Weekly August 2005 for one year
Had a Simple mastectomy left side after Mamo showed incresed micro-calcifications. Jan. 17 2006.
Brain MRI Feb.2006--All Clear
August 28, 2006 Last Weekly Herceptin.
October 2006--Colonoscopy, 6 Polyp's removed--all B9
PET Scan July 2007
Abdominal MRI Oct. 2007---2 Right Kidney Cysts
Core Biopsy-- Lump on Scar Line 1-10-08---B9
Brain MRI 6-2008--All Clear
PET/CT Scan 6-2008
Sept. 8 2008, 4CM area removed from mastectomy scar line. Proved to be B9.
PET/CT Scan-- July 2009 --All clear
August 17,2009 ---Had Port Removed
6 Years NED -- April 5,2011
DX'd with Melanoma left arm 10-10-2011
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07-31-2010, 07:25 PM
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#4
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Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
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Re: high blood levels of Coenzyme Q MAY be associated with higher risk of breast canc
Don't know about the CoQ yet. I think I'll do some research, but, Alice, I LOVE the new kitty avatar! Darling!!!!! Kitty cats make me smile!
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
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08-02-2010, 02:47 PM
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#5
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Senior Member
Join Date: Feb 2010
Location: TN
Posts: 175
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Re: high blood levels of Coenzyme Q MAY be associated with higher risk of breast canc
Seems like we need to have a review on why earlier studies were indicating just the opposite of this one. At least one CAM regimen I know of recommends 100 mg of CoQ10 for breast cancer prevention. (see http://www.nosurrenderbreastcancersu...ost?id=4807927 ) , particularly for Endocrine-responsive BC.
bird
__________________
Male Breast Cancer, DX 5/15/09, IDC, STAGE 1, 1.7 cm, HER2+++, ER+(95%)/PR+(75%), Ki67 40%, grade 3, 0/5 nodes, TX: mastectomy, TCH finished 7/19/10, radiation 6 wks., Tamoxifen on going, bisphosphonate 24 mos.
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08-02-2010, 03:04 PM
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#6
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Senior Member
Join Date: Apr 2009
Location: La Quinta, Ca
Posts: 253
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Re: high blood levels of Coenzyme Q MAY be associated with higher risk of breast canc
I have been taking 300mg of Coenzyme Q for five years based on a study that said it made Herceptin more effective. None of my oncologists have said anything about it. Hope clarity is coming on this soon. I would love to stop taking it.
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