Like a climber scaling a rock face, a migrating cancer cell has to keep a tight grip on the surface but also let go at the right moment to move ahead. Chan et al. reveal that the focal adhesion kinase (FAK) coordinates these processes to permit forward movement. The study was published online April 13 (
http://www.jcb.org) and will appear in the April 20 print issue of the Journal of Cell Biology.
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