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FISH Results-High Level Amplication
My HER2 ratio is 9.30 (High Level Amplication per the Pathology report.)
(The actual ratio is 139.32 divided by 14.98 CEP 17 chromosomes.) The FDA kit used was Pathvysion. I have been watching ratios disclosed in members e-mails and it appears that mine is on the high end. Oncologists tell me that the HER2 actual ratio's only significance is to determine HER2 status and that a higher ratio does not indicate a more aggressive cancer-you are either HER2+ or HER2-.
I would appreciate feedback. Thanks...Lynne
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DX 12/04/07 via mammogram(calcifications)-age 54-right breast
Biopsy revealed DCIS with 2mm of IDC-3 cores out of 5
HER2+ High Level Amplication per FISH(9.30 ratio)
Histologic Grade 2/3
architectural pattern: mostly cribriform with lobular cancerization
ER-(0)PR-(0)
12/20/07 Bilateral mastectomy. 2.5cm of DCIS plus Paget's disease of nipple (no additioanl IDC)
Node Negative-3 nodes per sentinel
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