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Old 11-11-2010, 12:23 AM   #1
harrie
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Actenol/Fosomax for bones
Does anyone have any information regarding the length of time to be on a biophosphonate such as Actenol or Fosomax for osteopenia or osteoporosis? I am interested in knowing if there is a maximum duration of time one should be on these meds for optimum benefit and minimum risk of side effects such as ONJ (osteonecrosis of the jaw).
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1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen

2006:
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Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy

2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
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Last edited by harrie; 11-11-2010 at 12:25 AM..
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Old 11-11-2010, 12:40 AM   #2
pibikay
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Re: Actenol/Fosomax for bones
My wife had 10 doses of Zoletec in 3 week intervals.Then when she was started on Tykerb Zoletec was stopped
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ossousmetstatis in vertbrae secondaries L4=L5secondary
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Taxotrne Zylotec started 16th March
Herceptin added 5th April.9th Herceptin over on 20th Sep '10.Started on Tykerb and Xeloda on 22nd Oct2010TYKERB 4 TAB A DAY XELODA 4 TAB A DAY ONE WEEK ON ONE WEEK OFFZoletrust infusion every 4 months.Lesion in Brain 3D CRT Radiation started on 1st Feb'12 for 20 days ,5 days a week for 4 weeks.Devloped a small lump in breast.Xeloda stopped from 11th April '12.On Taxol.After 3 cycles of Taxol Taxol stopped.Back to Xeloda regime from 3rd July
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Old 11-13-2010, 10:50 AM   #3
Kim in DC
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Re: Actenol/Fosomax for bones
The experts say to stay on 5 years and then re-evaluate. Onj usually occurs when the chemo suppresses your immune system and you have dental surgery. There is evidence that this class of drugs also fights breast cancer. You have to
way the odds.

Kim
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1/15/2005 Navelbine/Herceptin
4/2005 radiation and Herceptin
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2/12/2008 skin biopsy positive
2/14/2008 met to sternum, possibly right breast
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3/19 start tykerb xeloda
Right breast confirmed met
5/15/08 skin mets gone, no hypermetabolic activity in breast, sternum healing
8/24/08 scans still look good. sternum still active with scarring. No evidence of progression
10/08 Progression in sternum
12/08 Start TDM1 trial
1/09 Scans show stable
12/09 1 year on TDM1 still stable
10/10 progression in chest and liver
11/10 false positive of liver mets; tykerb and herceptin
4/11 Tykerb/Herceptin/Xgeva
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Old 11-14-2010, 03:57 PM   #4
Chelee
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Re: Actenol/Fosomax for bones
Harrie,
I had hoped to find the article I just read on this the other night...I found it very interesting. But it did state just what Kim said in her post. I've had alot of jaw pain since starting Zometa and was told to go off of it when I went to UCLA. I need to see a dentist and hope I don't have ONJ. So you do want to do your homework and be very careful with any of these drugs.

Chelee
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Results to FISH was unsuccessful--this happens less then 2% of the time.
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