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Old 10-30-2009, 03:40 AM   #1
chrislmelb
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AI after 5 years

Hi everyone, i don't visit heaps but always like to get feedback from you all.
I am wondering what the latest trend is regarding AI after being on them for 5 years? I am not there yet but feel quite panicky at the thought of going off them. I look forward to less aches and pains but not the return of cancer. I think i was on Tamoxifen for about 15 months before i switched to Arimidex. Now i am on Femara. I'm about 1 year ahead of myself but interested to hear early!
Thanks
Christine
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Christine

DX Sept 03 age 40 Stage 2B Grade 3 mastectomy (after 2 prior breast conserving surgeries)
"at least" 2.3 cm 3/12 nodes ER+/PR+ Her2+++
8 FEC. Tamoxifen then Arimidex. Ovaries out.
"late" Herceptin for 2 years (18months after chemo) on HERA trial. finished Herceptin Nov 2007.
Multiple bone mets May 2012 and now liver August 2012.
Abraxne, Herceptin and Zometa.
June 2013 Tykerb, Xeloda and Xgeva
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Old 10-30-2009, 03:11 PM   #2
tricia keegan
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Re: AI after 5 years

Hi Christine,
I think the jury is still out on this one. I was dx in '05 and am currently having one of those mets scares we all go through.
Assuming my mri is benign I also want to continue the arimidex for more than five years and hate stopping it.
A friend of mine just recently made this decision, and although she had wanted to remain on arimidex, her original dx was dcis and her2- so her onc felt it safe to allow her to stop.
I'll be interested in reading any other comments or replies to your question.
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Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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Old 10-30-2009, 03:25 PM   #3
WolverineFan
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Location: Owasso, OK
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Re: AI after 5 years

My onc just put me on Femara this week and told me I need to take it for 5 years. She also said that there are studies currently taking place that are examining the benefits, if any, of staying on it for 10 years. She told me to be prepared because at the end of my five years, she may tell me I need to take it another five years. I am not sure if the recommendation to lengthen the time (if that's what is decided) will come out before you are finished next year, but you might want to visit with your onc about it.

Good luck!
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Hayley
Oklahoma

3/35/2009 - Diagnosed, age 39
5/7/09 - Mastectomy and reconstruction started. Two tumors found. Tumors were side by side. DCIS tumor was 2.8 cm, ER-, PR-, grade 2. Invasive tumor was 1.1 cm, poorly differentiated, grade 3, ER+90%, PR+95%, HER2+3. Thankfully, no node involvement.
5/29/09 - Second surgery resulting from difficulty healing from mastectomy.
6/2/09 - Began Herceptin treatments
6/23/09 - Began Taxotere and Carboplatin treatments along with Herception every 3 weeks.
10/06/09 - Completed Taxotere and Carboplatin - Yeah!!!
10/27/2009 - Herceptin maintenance and began Femara
12/10/2009 - 2nd stage reconstruction surgery
2/2010 - Body rejected saline implant
3/18/2010 - Second stage reconstruction using silicone implant
5/4/10 - Completed Herceptin - YEE-HAA!
May '10 - Body rejects silicone implant...taking a break.
11/29/10 - Hysterectomy
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Old 10-30-2009, 07:21 PM   #4
Jean
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Re: AI after 5 years

Ditto....
My onc. also said that it looks like I will remain on AI another 5 yrs.

jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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Old 10-30-2009, 08:15 PM   #5
Barbara2
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Re: AI after 5 years

At the 5 year mark, my onc opted to continue the AI stating that some studies are looking at using the AI for ten years...again, feeling that the benefits were greater than the risks.
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Blessings and Peace,
Barbara

DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.

Accepting the gift of life, I give thanks for it and live it in fullness.
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