Madrid BC conference: effect of resveratrol (polyphenol from red wine) on her2+ER+bc

[Lani]

cell line BT 474 elucidated--sounds like a lot of gobblydygook (?sp) but
shows many different good effects on the cell line which best approximates
those who are are her2+ and ER+ (nice to even see research done with that cell line, as her2+ER+ bc patients represent only ~10% of bc patients)

Resveratrol downregulates acetyl-CoA carboxylase
alpha and fatty acid synthase by activating
AMP-activated protein kinase and suppressing the
mammalian target of rapamycin signal pathway
S Yoon, B-W Park, K-S Kim
Yonsei University College of Medicine, Seoul, Korea
Breast Cancer Research 2007, 9(Suppl 1):P8 (doi: 10.1186/bcr1714)
Expression of HER2 is reported to be increased in approximately 30%
of human breast carcinoma. Fatty acid synthase (FASN) was expressed
higher in HER2-overexpressing breast cancer cells. Resveratrol (3,5,4?-
trihydroxystilbene), a red-wine-derived polyphenol, has been shown to
suppress cancer cell proliferation, and to interfere with the several
signaling pathways and induce apoptosis. We investigated the effects
of resveratrol on the expression of lipogenic enzymes in BT-474 cells,
in which HER2 overexpresses cells. Resveratrol treatment to BT-474
cells resulted in inhibition of acetyl-CoA carboxylase alpha (ACCalpha)
and FASN expression and a strong activation of AMP-activated protein
kinase (AMPK), which could be mimicked by the changes caused by
AICAR treatment or forced expression of constitutively active AMPK
mutant. The decreased ACCalpha and FASN expressions by
resveratrol were abolished by overexpression of dominant-negative
AMPK mutant. The activation of AMPK was accompanied with the
reduction of the mammalian target of rapamycin (mTOR), which plays a
key role in the upregulation of ACCalpha and FASN expression in
BT-474 cells. These results indicate that downregulation of HER2-
mediated ACCalpha and FASN expression by resveratrol is regulated
through suppressing the mTOR signaling pathway resulting from the
activation of AMPK in breast cancer cells.

[Belinda]

Wow. So confusing though - recent articles seem to suggest any alcohol is bad for bc. Would be good if someone could extract high-grade resveratrol in non-alcoholic capsule form. Maybe there's a market for a good organic non-alcoholic resveratrol-laden 'wine' - I'd buy it! I live in Australia's best wine state - more wine here than bc! Wish I had the connections to get that made and to market!

[R.B.]

Caution. It is easy to confuse the effect of wine with things in it which includes alcohol (ethanol).

Resveratrol is a compound found in grapes that gets into juice and wine when grapes are pressed.

The trial is on Resveratrol and not red wine ( at least that what the summary appears to say)

You can buy supplements which contain Resveratrol. Lots of companies do them.

http://www.vitacost.com/productResul...tt=Resveratrol

Most sources agree that medium to high ethanol (alcohol) is bad for you.

The answers on low alcohol consumption (and how much is low) are less clear because the body is complex.



RB