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Old 06-11-2008, 01:40 PM   #1
Faith in Him
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Join Date: Jul 2007
Location: Northern California
Posts: 764
Question about Chemo/target therapy

As you all know, I'm still fairly new at this. '07 was the year I learned I had bc. In that year Tykerb and Ixempra was approved and Avastin was on the horizion. This year I haven't seen much although I know there are new drugs in the works. Was '07 just a good year for new treatments? I guess, I was hoping that new drugs came out all the time.

Thanks,
Tonya
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DX 02/01/07
2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
03/09 - Tykerb/Xeloda
05/10 - Tram flap to fix wound
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Old 06-12-2008, 08:46 AM   #2
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
Tonya,
New drugs are always in the pipeline. When I was diagnosed with mets in 04, I found this site and used it ONLY to read the articles of interest. Getting a sense that a LOT of research was going on, particularly for Her2, gave me hope.

Although herceptin was at that time available for stage IV cancer, it wasn't approved for early stage adjuvant treatment until sometime in I think 2006. At that time I felt the same way as you - when are more drugs going to be coming??? Then as you note, Tykerb, Ixempra, Avastin all in the last year.

The pipeline is not dry at all...but I agree it seems to take too darn long!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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