|
07-28-2012, 04:07 AM
|
#1
|
Senior Member
Join Date: Mar 2006
Posts: 4,778
|
Highly recommended reading--more from Max Wicha, MD
same pdf has important paper from Javier Menendez on metformin as well
The secrets of her2+ breast cancer and how to treat/cure it are becoming more and more clear and faster and faster...
read the fourth and third articles here:
http://www.landesbioscience.com/jour...1-15-Malik.pdf
|
|
|
07-28-2012, 09:07 AM
|
#2
|
Senior Member
Join Date: Feb 2009
Posts: 1,526
|
Re: Highly recommended reading--more from Max Wicha, MD
Thanks Lani
Not sure I totally understood all the science but what jumped out again in the fourth article was the involvement of NF-KB again.
Ellie
|
|
|
07-28-2012, 09:18 AM
|
#3
|
Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
|
Re: Highly recommended reading--more from Max Wicha, MD
Much appreciated, Lani!
A.A.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
|
|
|
07-28-2012, 09:33 AM
|
#4
|
Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
|
Re: Highly recommended reading--more from Max Wicha, MD
menendez is another of my favorite researchers
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
|
|
|
07-29-2012, 08:27 AM
|
#5
|
Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
|
Re: Highly recommended reading--more from Max Wicha, MD
What I read from this is that there is more identification of the cellular pathways at the molecular biology levels that are being identified. This means that disease progression may be stopped using multiple means, rather than a single method, such as Herceptin. The disease can find its way around Herceptin treatment in some cases, which is why identifying other important roadblocks is important. If you can delay disease progression for 100 years, you have stopped the impact on patients. That is the goal of these researchers. Many of the pathways are critical to even normal cells, the idea is to block the ones most critical to the cancer cells. Think of it as making the 125 pound cancer cell that has been built to be a runner now have to carry the 50 extra pounds of the 175 pound woman that walks five miles per day. The woman with the extra weight now has a fair chance to match the pace and win the race.
Lani's contacts design the drugs. Mine get them to patients. The goal is that we get the best treatment options possible to patients.
|
|
|
07-29-2012, 09:03 AM
|
#6
|
Senior Member
Join Date: Mar 2006
Posts: 4,778
|
Re: Highly recommended reading--more from Max Wicha, MD
I wish I HAD contacts who designed drugs
I only read the literature,try to attend conferences and try to engage other conference attendees (often extremely difficult)
|
|
|
Posting Rules
|
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
HTML code is Off
|
|
|
All times are GMT -7. The time now is 09:10 AM.
|