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Old 01-19-2008, 01:13 PM   #1
Paris
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Exclamation I had an abnormal stress echo today- Can anyone help me with this?

Hi, I am cross posting this from the herceptin/tykerb board. I saw a cardiologist because I was having heart palpitations and shortness of breath whle running. I had a stress echo and my heart is adding in many extra beats. Also, the left lower wall of my heart doesn't contract well when physically stressed. It is totally normal when resting. I now have to have a heart catheterization. While the cardiologist thinks it's no big deal, the idea of having a catheter placed upto my heart makes me nervous! He and my onc. are not sure it's from the herceptin (I am about to go for round 13). It could be a blockage but I am in excellent health apart from having breast cancer. Oddly enough, my MUGA scans are 67% but I am lying still so the problem doesn't show up.

Have any of you had anything remotely like this? If you had a heart catheterization what was it like? I go on Tuesday for the procedure and until then I'm not allowed to exert myself at all which is hard for me since I enjoy running. It's so tricky to know what the culprit is.

On a side note, it seems like alot of people who have to be taken off herceptin have it happen around cycle 13.

Hoping some of you will chime in. Thank God for zoloft!

Jamie
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Diagnosed 11/06 IDC left breast Stage 1, High Grade w/extensive High Grade DCIS. Right breast extensive hyperplasia w/calcifications.
ER-/PR- HER2+++
Bi-lateral masectomy 12/15/06 w/expanders
SNB Node Negative
Chemo Taxotere, Cytoxan 2/07-4/07
Herceptin Started 5/07
Exchange surgery 6/15/07
Herceptin stopped after 12 rounds due to herceptin induced cardiomyopathy
On heart meds 'til?
Age 40 at diagnosis
Cancer may have been a defining moment but it does not define me!
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Old 01-19-2008, 07:07 PM   #2
Lolly
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Hi Paris; I had to have a catheterization for an issue unrelated to Herceptin, and it was pretty painless if a bit weird: They gave my a sedative so I'd be relaxed but still awake, and I got to watch the whole thing on the screen along with the doctors. While the catheter was in my heart, there was some slight discomfort as when the catheter would brush up against the wall of my heart it would cause a slight "zing" feeling, kind of like a very, very slight electric shock. But all in all a simple procedure, and it seems a necessary one for you so they can determine what's causing the problem. Hope you can remain on Herceptin.

<3 Lolly
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 01-20-2008, 05:03 AM   #3
Mary Anne in TX
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Hi Paris!
My husband has had 2. One when he had a heart attack and one just to check the functioning of his heart. He did just fine. The 2nd one told him his heart was super and gave him years of peace.
I'll sure be thinking of you on Tuesday and praying for "running results"! Hope it's just some left overs from chemo. ma
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Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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Old 01-21-2008, 09:12 PM   #4
Joan M
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Paris,

Perhaps you should consult with another cardiologist for a second opinion to get additional feedback.

If possible, you might try a major medical center where they see a lot of different conditions.
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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