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11-11-2009, 11:51 AM
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#1
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Senior Member
Join Date: May 2006
Posts: 3,142
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Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
http://www.caring4cancer.com/go/canc...wsItemId=44263 |
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11-11-2009, 04:41 PM
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#2
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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Re: Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
Thanks Elaine , I wonder if this applies to DCIS?
Many women are still not tested when they're dcis and it may well make a difference in the future I think.
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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11-14-2009, 05:14 PM
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#3
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Senior Member
Join Date: May 2006
Location: Haarlem, the Netherlands
Posts: 835
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Re: Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
I seem to remember that there's a relatively high percentage of DCIS that's HER2 positive. Yet many DCIS's don't turn into cancer. Hmm.
Jacqueline
__________________
Diagnosed age 44, January 2004, 0.7 cm IDC & DCIS. Stage 1, grade 3, ER/PR pos. HER2 pos. clear margins, no nodes. SNB. 35 rads. On Zoladex and Armidex since Dec. 2004. Stopped Zoladex/Arimidex sept 2009 Still taking mistletoe shots (CAM therapy) Doing fine.
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11-15-2009, 06:17 AM
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#4
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Re: Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
Elaine, i fit the bill on this one, 7mm tumor, node neg, then recurrance in 1 1/2 yrs. Interesting...but then Herceptin was not approved for early stage way back then....That I believe would have made a difference!
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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11-15-2009, 09:40 AM
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#5
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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Re: Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
50% of all DCIS starts as Her2+ but only about 20% remain so as invasive cancer.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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11-15-2009, 12:01 PM
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#6
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
Maybe getting clear margins during surgery has something to do with it. If the surgeon doesn't get every single cancer cell out during the surgery it might be able to reproduce even if radiation and/or chemo are offerred to the patient.
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11-17-2009, 12:29 PM
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#7
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Senior Member
Join Date: Sep 2005
Posts: 49
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Re: Even Small HER2-positive Breast Cancers Have a Higher Risk of Recurrence
I had quite a long discussion about this with my oncologist when I had a recurrence in 2005. My tumor was HER2 +++, ER/PR +, 0.7CM. He said that women like me fell into a gray area and he didn't want to give chemo in order to give me Herceptin because he thought the risks outweighed the benefits. I am on Arimidex and doing great. This is just another bullet in the breast cancer arsenal for women who test + for HER2.
__________________
Petesmom
"Treat each day as a new life"
Diagnosis
1998 IDC, 8mm tumor; node neg Her2-; ER/PR + lumpectomy right breast; rads; Fareston for 5 yrs;
2005 recurrence right breast; DCIS with IDC 7mm (total involvement), Her2+++. ER/PR+; simple mast; prophylactic ooph; Arimidex only
NED
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