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Old 07-30-2008, 04:54 PM   #1
Barbara H.
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Red face Need information about a surgical lung biopsy

Hi,
My CT scans have shown progressive inflammation since January. My oncologist has not been concerned but thought I should now see a pumonologist. I did today and it was recommended that I have a a surgical lung biopsy to determine exactly what is going on. This procedure requires a three day hospital stay.
Possible results:
lung mets: unlikely (no nodules)
inflammation (various causes) possible
inflammation from the Herceptin MCC DM 1 trial drug (This is most likely.)

I am very worried because this drug is really working for me and it is possible that I may need to go off the trial if it is causing this.

Also, I am interested in knowing about the recovery for this procedure. I need to set up my classroom and start school in September. I am also curious about how much pain is associated with this procedure.

I am leaving for Michigan on Friday to spend a week with my family and am quite unhappy about having this hanging over my head.

Best regards,
Barbara H.
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Old 07-30-2008, 05:22 PM   #2
Ceesun
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Barb, Is this an actual open surgical biopsy? I have had 2 needle biopsies of lung which sound scarier than they actually were. They were done as an outpatient and were not painful--collapsed lung was a concern, too...but not the norm. I suspect what you are describing might be different. Let me know if I can help with more info. Ceesun
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Old 07-30-2008, 05:50 PM   #3
Barbara H.
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open surgical biopsy

They want to do an open surgical biopsy. I think they want to make sure they get enough tissue to determine if it is a reaction to the drug or general inflammation. I still have to meet with the surgeon and will know more then.
Thanks,
Barbara H.
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Old 07-30-2008, 06:25 PM   #4
madubois63
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I had VA (video assisted) biopsy of the lung twice. They go in through the back, take some pics (I have full color pics of my cancer - yuk) and snip what they need. You are asleep, so you don't feel anything for a while. It may be a little painful afterward, but it also depends on if you are in any pain now. I was experiencing fluid in the lung and having difficulty breathing at the time, so I was taking pain meds regularly. just ask, they will give you what you need. Make sure you tell the doc to have the orders there just in case. Don't worry too much and try to enjoy your trip. It's not as bad as you are imagining and you'll be fine in a few days!!
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Maryann
Stage IV Inflammatory BC 1/00
Mod Rad Mastectomy 24nod/5+
Adriomycin Cytoxin Taxol
Tamoxifen 4 1/2 yrs
Radiation - 32 x
Metastatic BC lung/liver 10/04
thorocentesis 2x - pleurodesis
Herceptin Taxatiere Carbo
Femera/Lupron
BC NED 4/05
chemo induced Acute Myeloid Leukemia 5/06
Induction/consolidation chemo
bone marrow transplant - 11/3/06
Severe Host vs Graft Disease of liver
BC mets to lung 11/07
Fasoladex Herceptin Zometa Xeloda
GVHD/Iron overload to liver
Avascular Necrosis/morphine pump 10/10
metastatic brain tumor
steriotactic radiosurgery
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Old 07-30-2008, 07:01 PM   #5
Joan M
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Hi Barbara, Sorry to hear that you need to have a biospy to figure out what's happening with your lung. I had a needle biospy and then video-assisted thoracic surgery to remove my nodule but there was not doubt after that biopsy that the nodule was malignant. Will you be having a VATS procedure for the biopsy? I understand the reasoning for the surgery as opposed to the biopsy. It's very hard to get a biopy with a definitive diagnosis from a small lesion. I went through all that. So I guess they want to get enough tissue to make a definitive diagnosis. I think it's really wonderful that that you are doing well on the trial. You are in my prayers. Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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