For Those With Lung Mets -- Abstract To Take With You

[Lani]

FROM MY PREVIOUS POST MANY SAID THEY WERE TAKING IT WITH THEM TO THEIR APPOINTMENTS.

HERE IS A PUBMED ABSTRACT SHOWING HOW TO ACCESS THE ORIGINAL ARTICLE ON THESE SAME 4 GENES FOUND TO BE RESPONSIBLE FOR LUNG METS

Nature. 2007 Apr 12;446(7137):765-770.
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

Gupta GP,
Nguyen DX,
Chiang AC,
Bos PD,
Kim JY,
Nadal C,
Gomis RR,
Manova-Todorova K,
Massague J.
[1] Cancer Biology and Genetics Program, [2] These authors contributed equally to this work.
Metastasis entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake distant organs. Using genetic and pharmacological approaches, we show that the epidermal growth factor receptor ligand epiregulin, the cyclooxygenase COX2, and the matrix metalloproteinases 1 and 2, when expressed in human breast cancer cells, collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis. These findings reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential, and how such biological activities may be therapeutically targeted with specific drug combinations.
PMID: 17429393 [PubMed - as supplied by publisher]