D-Limonene vs. Cancer

[Tom]

I have been looking into this one for some time now. I have decided to add this to Mom's daily supplements via LEF.org's formulation of CoQ-10, which now contains d-limonene. D-limonene is also available as a single supplement from TheVitaminShoppe.com

http://www.mskcc.org/mskcc/html/1157...ab=HC#drugherb


Here is a brief excerpt from the article:

MECHANISM OF ACTION

The exact mechanism of action is unknown. D-Limonene and its metabolites, perillic acid, dihydroperillic acid, uroterpenol, and limonene1,2-diol, may inhibit tumor growth via inhibition of p21-dependent signaling and apoptosis resulting from induction of the transforming growth factor beta-signaling pathway (4) (8). D-Limonene metabolites also cause G1 cell cycle arrest, inhibit posttranslational modification of signal transduction proteins, and cause differential expression of cell cycle- and apoptosis-related genes (6). Animal studies show activity of D-limonene against pancreatic, stomach, colon, skin, and liver cancers (3). Data also indicate that D-limonene slows the promotion/progression stage of carcinogen-induced tumors in rats (9) (11).