predicting her2 progression in early stage cancer

I have recently read of uPA short for urokinase plasminogen activator and its inhibitor PA1-1. About 45 percent of breast cancer patients have high levels of these proteins .These women have also higher rates of cancer spread.Has anyone monitored uPA levels in early stage setting to evaluate risk for disease progression? Increased uPA levels are reported to be a stronger prognostic variable than tumor size, nodal status ,tumor grade, ER,PR, p53, AND her2 status.

Also, has anyone who is ER, PR negative her2 positive with early stage cancer had any reliable genomic testing done to define their genetic signature? A bad genetic signature along with a bad primary tumor signature are unfavorable features which work together causing cancer progression.

I would like more info one this subject. Can you post where to find it? Also very interested in genetic testing since I have 2 daughters and I was dx'd pre menopause, and before age 40.
Cathy

Genetic testings for hereditary breast cancer which are available now, so far, are: BRCA1 & BRCA2 gene mutations.

It's a good idea to be tested, unless possible lack of privacy is a bigger issue for you.

Cathy, I agree with JOJO that Brac1 and 2 are the only tests currently available for your daughters.

I think the uPA test and tests for genetic signature involve microrrays and computer analysis of many genetic markers which are still being researched and not ready for prime time.

I might add that a new blood protein marker test-stat5 can predict metastatic potential and aggressiveness of primary breast tumors.

Recent new research too of coexistence of p53 with her2 implicates poor prognosis.

Can I ask what one is supposed to do with that information?

Sometimes I feel that some knowledge is better not known...I mean talk about upsetting yourself when you should have faith and believe that you can survive this disease.