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Old 01-30-2020, 05:19 PM   #1
Nguyen
Senior Member
 
Join Date: Nov 2005
Posts: 296
Over come resistance to Neratinib with Affinitor.

Given that Neratinib has been out not that long ago, and already resistance to it has developed as in

Neratinib resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4.

https://www.ncbi.nlm.nih.gov/pubmed/28152547

The below news is welcome. Essentially Neratinib and Affinitor could overcome this resistance.

Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers

https://www.sciencedirect.com/scienc...835?via%3Dihub
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