HER2 Support Group Forums - View Single Post - any tumor tests to predict which chemos work better?

Joan M · 02-21-2012, 03:41 PM

Here's something in the news about the potential of biomarkers to indicate which chemos work best in which patients. It's from the European Commission.

http://cordis.europa.eu/fetch?CALLER...1802&RCN=34317

At SABCS, there was a lot of chatter about how over the last few years the Europeans are really getting it together. As I understood it from a few oncs I talked with, many more patients participate in breast cancer clinical trials than in the U.S., and scientists work more collaboratively across institutions and are more willing to link their databases.

Joan

02-21-2012, 03:41 PM	#35
Joan M Senior Member Join Date: Oct 2007 Posts: 1,851	Re: any tumor tests to predict which chemos work better? Here's something in the news about the potential of biomarkers to indicate which chemos work best in which patients. It's from the European Commission. http://cordis.europa.eu/fetch?CALLER...1802&RCN=34317 At SABCS, there was a lot of chatter about how over the last few years the Europeans are really getting it together. As I understood it from a few oncs I talked with, many more patients participate in breast cancer clinical trials than in the U.S., and scientists work more collaboratively across institutions and are more willing to link their databases. Joan __________________ Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!