HER2 Support Group Forums - View Single Post - for those with (or worried about) brain mets Avastin seems to cross the bbb

heblaj01 · 03-02-2007, 04:00 PM

I am a bit surprised that the trial used Irinotocan (which has relatively high toxicity) instead of Temodar to partner with Avastin.

I found this link to a patient whose onc prescribed this combo off label:
http://64.233.167.104/search?q=cache...n&ct=clnk&cd=5
I noticed among several trials using Irinotocan in combination with an other drug for brain cancer one trial of irinotocan +Temodar ,for children,taking place at Duke university.

03-02-2007, 04:00 PM	#3
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	I am a bit surprised that the trial used Irinotocan (which has relatively high toxicity) instead of Temodar to partner with Avastin. I found this link to a patient whose onc prescribed this combo off label: http://64.233.167.104/search?q=cache...n&ct=clnk&cd=5 I noticed among several trials using Irinotocan in combination with an other drug for brain cancer one trial of irinotocan +Temodar ,for children,taking place at Duke university.