HER2 Support Group Forums - View Single Post - Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

Rolepaul · 03-04-2013, 01:42 PM

The ability to decide on what path to take for treatment is difficult. I do not think that there has been a suitable dose to allow successful treatment at the 80 mg dosing. We did not see progress with Nina until there was 10 doses at 80 mg for 62 kg Nina. We actually saw additional improvement at 100 mg for 65 kg. This 1.5 mg/kg dosing was also important for Carol, Mario's wife. It does not occur in 2 weeks, but in 10-16 weeks. It should however, stop progression of the disease immediately. Any edema is probably due to the cancer cells dying. Do not give up. Depocyte is really hard on the brain. I am in the business of making these drugs, you want to use a monoclonal Antibody if at all possible.
Superior Paul

03-04-2013, 01:42 PM	#129
Rolepaul Senior Member Join Date: Jan 2012 Location: Boulder Colorado as of January 2013 Posts: 389	Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase The ability to decide on what path to take for treatment is difficult. I do not think that there has been a suitable dose to allow successful treatment at the 80 mg dosing. We did not see progress with Nina until there was 10 doses at 80 mg for 62 kg Nina. We actually saw additional improvement at 100 mg for 65 kg. This 1.5 mg/kg dosing was also important for Carol, Mario's wife. It does not occur in 2 weeks, but in 10-16 weeks. It should however, stop progression of the disease immediately. Any edema is probably due to the cancer cells dying. Do not give up. Depocyte is really hard on the brain. I am in the business of making these drugs, you want to use a monoclonal Antibody if at all possible. Superior Paul