HER2 Support Group Forums - View Single Post - Coronavirus - is low vitamin D a factor

R.B. · 01-29-2020, 02:46 PM

Given the recent outbreak of the Corona virus, and that those with weakened immune systems may be at greater risk of more serious outcomes, I post this for general information.

There is significant evidence that low vitamin D is a factor in risk of acquisition and progression of respiratory conditions, as set out in ‘Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials’ https://journals.plos.org/plosone/ar...l.pone.0065835

(Some links to explore - Low vitamin D is associated with increased risk of and poorer outcomes in pneumonia and other conditions involving compromised lung function eg COPD, asthma, bronchitis, influenza etc

https://vitamindwiki.com/Breathing Breathing

https://vitamindwiki.com/tiki-index.php?page_id=1324 Pneumonia Risk, intensity, and mortality

https://vitamindwiki.com/COPD+Overview COPD

https://vitamindwiki.com/Overview+Asthma+and+Vitamin+D Asthma

https://vitamindwiki.com/tiki-index.php?page_id=1304) Overview Influenza and vitamin D

I set out a few lines from studies below. I find the results very thought provoking.

Vitamin D insufficiency is very wide spread globally and particularly in elderly groups. Interestingly a 2019 study titled ‘A Comparison Study of Vitamin D Deficiency among Older Adults in China and the United States’ observed:

“We found that the mean 25(OH)D concentration was lower in China than in the US (45.1 vs. 83.5 nmol/L), with Chinese elderly lower than American elderly for every age group. 70.3% in China and 17.4% in the US were considered as vitamin D deficiency (30.6% and 3.4% were considered as severe deficiency)”
https://www.nature.com/articles/s41598-019-56297-y

“Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia (CAP): a case-control study”

“According to findings, a low level of 25(OH)D is associated with a higher incidence of CAP and more severe disease. It is recommended to pay more attention to vitamin D deficiency in infectious diseases, particularly in CAP patients.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692194/

“Relationship Between Vitamin D Status and Viral Pneumonia in Children”
“As vitamin D status decreased, the odds ratio (95% confidence interval) for VP showed an increasing trend [sufficiency (0.3; 0.2–0.5), insufficiency (0.9; 0.6–1.3), deficiency (2.0; 1.3–2.9), and severe deficiency (51.7; 7.2–372.2)]. The median (IQR) serum 25(OH)D level in the VP subgroup who accepted mechanical ventilation was significantly lower than that in the nonmechanical ventilation subgroup [12.9(6.5–22.5) ng/mL versus 20.8 (14.2–28.0) ng/mL] (P < 0.001). Poor vitamin D status might be related to the susceptibility and severity of VP in children.”
https://www.liebertpub.com/doi/abs/1...ournalCode=ped

Lots more studies on risk or respiratory illness and Vit D . . . for example

https://vitamindwiki.com/tiki-index.php?page_id=1324

Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia

Results Severe 25-hydroxyvitamin D deficiency (<30nmol/L) was common in this population (15%) and was associated with a higher 30-day mortality compared to patients with sufficient 25-hydroxyvitamin D(>50nmol/L) (OR 12.7, 95%CI 2.2-73.3, p = 0.004).

VitaminDwiki poses the thought “China's Coronavirus can most likely be fought by Vitamin D” ????? (my question marks) – Jan 2020 https://vitamindwiki.com/China%27s+C...80%93+Jan+2020

Suggesting it provides an opportunity for a study – I too had wondered it Vit D supplementation may ameliorate progression, and that study data would be immensely valuable to determine if there was a correlation between vitamin D status and severity of the disease.

And from the WHO site https://www.who.int/elena/titles/vit...a_children/en/
• Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P et al.
BMJ. 2017;356:i6583.
• Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Bergman P, Lindh AU, Björkhem-Bergman L, Lindh JD.
PLoS One. 2013; 8:e65835.
• Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis
Charan J, Goyal JP, Saxena D, Yadav P.
Journal of Pharmacology and Pharmacotherapeutics. 2012; 3:300-3.

01-29-2020, 02:46 PM	#1
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions Given the recent outbreak of the Corona virus, and that those with weakened immune systems may be at greater risk of more serious outcomes, I post this for general information. There is significant evidence that low vitamin D is a factor in risk of acquisition and progression of respiratory conditions, as set out in ‘Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials’ https://journals.plos.org/plosone/ar...l.pone.0065835 (Some links to explore - Low vitamin D is associated with increased risk of and poorer outcomes in pneumonia and other conditions involving compromised lung function eg COPD, asthma, bronchitis, influenza etc https://vitamindwiki.com/Breathing Breathing https://vitamindwiki.com/tiki-index.php?page_id=1324 Pneumonia Risk, intensity, and mortality https://vitamindwiki.com/COPD+Overview COPD https://vitamindwiki.com/Overview+Asthma+and+Vitamin+D Asthma https://vitamindwiki.com/tiki-index.php?page_id=1304) Overview Influenza and vitamin D I set out a few lines from studies below. I find the results very thought provoking. Vitamin D insufficiency is very wide spread globally and particularly in elderly groups. Interestingly a 2019 study titled ‘A Comparison Study of Vitamin D Deficiency among Older Adults in China and the United States’ observed: “We found that the mean 25(OH)D concentration was lower in China than in the US (45.1 vs. 83.5 nmol/L), with Chinese elderly lower than American elderly for every age group. 70.3% in China and 17.4% in the US were considered as vitamin D deficiency (30.6% and 3.4% were considered as severe deficiency)” https://www.nature.com/articles/s41598-019-56297-y “Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia (CAP): a case-control study” “According to findings, a low level of 25(OH)D is associated with a higher incidence of CAP and more severe disease. It is recommended to pay more attention to vitamin D deficiency in infectious diseases, particularly in CAP patients.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692194/ “Relationship Between Vitamin D Status and Viral Pneumonia in Children” “As vitamin D status decreased, the odds ratio (95% confidence interval) for VP showed an increasing trend [sufficiency (0.3; 0.2–0.5), insufficiency (0.9; 0.6–1.3), deficiency (2.0; 1.3–2.9), and severe deficiency (51.7; 7.2–372.2)]. The median (IQR) serum 25(OH)D level in the VP subgroup who accepted mechanical ventilation was significantly lower than that in the nonmechanical ventilation subgroup [12.9(6.5–22.5) ng/mL versus 20.8 (14.2–28.0) ng/mL] (P < 0.001). Poor vitamin D status might be related to the susceptibility and severity of VP in children.” https://www.liebertpub.com/doi/abs/1...ournalCode=ped Lots more studies on risk or respiratory illness and Vit D . . . for example https://vitamindwiki.com/tiki-index.php?page_id=1324 Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia Results Severe 25-hydroxyvitamin D deficiency (<30nmol/L) was common in this population (15%) and was associated with a higher 30-day mortality compared to patients with sufficient 25-hydroxyvitamin D(>50nmol/L) (OR 12.7, 95%CI 2.2-73.3, p = 0.004). VitaminDwiki poses the thought “China's Coronavirus can most likely be fought by Vitamin D” ????? (my question marks) – Jan 2020 https://vitamindwiki.com/China%27s+C...80%93+Jan+2020 Suggesting it provides an opportunity for a study – I too had wondered it Vit D supplementation may ameliorate progression, and that study data would be immensely valuable to determine if there was a correlation between vitamin D status and severity of the disease. And from the WHO site https://www.who.int/elena/titles/vit...a_children/en/ • Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P et al. BMJ. 2017;356:i6583. • Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Bergman P, Lindh AU, Björkhem-Bergman L, Lindh JD. PLoS One. 2013; 8:e65835. • Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis Charan J, Goyal JP, Saxena D, Yadav P. Journal of Pharmacology and Pharmacotherapeutics. 2012; 3:300-3. Last edited by R.B.; 03-12-2020 at 08:38 AM..