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Mandamoo · 04-02-2012, 02:20 AM

Can anyone help out with information on what the optimum dosages are?
I am currently on 4000mg of Xeloda daily (2000mg x twice a day) and tykerb 5 tablets a day
I have now done two cycles - was fine on the xeloda alone then added the Tykerb and the diarrhoea hit but it resolved with the week off the xeloda. I have now done a second cycle with both drugs but in my current week off the xeloda the diarrhoea hasn't resolved, my appetite is very poor and the fatigue is incredible.

My oncologist has suggested a dose reduction - to 7 pills a day (instead of 8) of the xeloda and keeping the Tykerb at 5 a day. Another option is to reduce to 6 xeloda a day and 4 tykerb.

Is there any data about what doses are effective. I am seeing a great result on my skin and hope to see the same in my lungs but I don't know if I can keep going at the current dosage. I want it to still be effective though…

Any tips from those who have used this in the past?
Thanks,
Amanda x

04-02-2012, 02:20 AM	#1
Mandamoo Senior Member Join Date: Jul 2011 Location: Melbourne, Australia Posts: 432	eloda and tykerb optimum dosage Can anyone help out with information on what the optimum dosages are? I am currently on 4000mg of Xeloda daily (2000mg x twice a day) and tykerb 5 tablets a day I have now done two cycles - was fine on the xeloda alone then added the Tykerb and the diarrhoea hit but it resolved with the week off the xeloda. I have now done a second cycle with both drugs but in my current week off the xeloda the diarrhoea hasn't resolved, my appetite is very poor and the fatigue is incredible. My oncologist has suggested a dose reduction - to 7 pills a day (instead of 8) of the xeloda and keeping the Tykerb at 5 a day. Another option is to reduce to 6 xeloda a day and 4 tykerb. Is there any data about what doses are effective. I am seeing a great result on my skin and hope to see the same in my lungs but I don't know if I can keep going at the current dosage. I want it to still be effective though… Any tips from those who have used this in the past? Thanks, Amanda x __________________ Amanda xx 40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11 Wife to my wonderfully supportive husband of 17 years! 22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old (L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins. Fec3, Taxotere and herceptin2 - stopped due to secondary diagnosis June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy! September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing. January 2013 - herceptin, carboplatin and Perjeta (compassionate access) April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.