HER2 Support Group Forums - View Single Post - Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

evlin75 · 12-01-2012, 12:51 PM

My daughter took xeloda with herceptin and tykerb after brain surgery followed by WBR several years ago. There was no negative interaction in her case. The xeloda did not seem to do anything for her and was discontinued.

At this time she is getting the IT therapy with herceptin 40 and topotecan weekly- and also IV therapy with herceptin and perjeta every three weeks. She continues taking the tykerb.

The cervical area of the spine mets has resolved . The other spine mets are stable- basically no change There is a questionable spot on the brain yet. The next MRI is in two weeks.

She started out in Chicago in August with just the low dose of 10 twice a week on the Herceptin IT. She has been on the 40 for a couple months. We are trying to persuade the doctor to up the dose of IT Herceptin. He will decide what to change after the next MRI.

12-01-2012, 12:51 PM	#91
evlin75 Senior Member Join Date: Sep 2007 Posts: 118	Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase My daughter took xeloda with herceptin and tykerb after brain surgery followed by WBR several years ago. There was no negative interaction in her case. The xeloda did not seem to do anything for her and was discontinued. At this time she is getting the IT therapy with herceptin 40 and topotecan weekly- and also IV therapy with herceptin and perjeta every three weeks. She continues taking the tykerb. The cervical area of the spine mets has resolved . The other spine mets are stable- basically no change There is a questionable spot on the brain yet. The next MRI is in two weeks. She started out in Chicago in August with just the low dose of 10 twice a week on the Herceptin IT. She has been on the 40 for a couple months. We are trying to persuade the doctor to up the dose of IT Herceptin. He will decide what to change after the next MRI.