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Re: metronomic chemo
Table 3. Ongoing studies featuring metronomic chemotherapy in HER2 positive breast cancer
Drugs Study design and population Primary outcome Study identifier Status
Pertuzumab, trastuzumab
and metronomic
cyclophosphamide
Open-label multicenter
randomized phase II
selection trial in the
elderly HER2รพ metastatic
breast cancer population
Progression free survival NCT01597414 Not yet open
Paclitaxel, doxorubicin, trastuzumab
and metronomic
cyclophosphamide
Phase II feasibility study in
locally advanced HER2-
positive breast cancer
Incidence of febrile
neutropenia
NCT01329640 Ongoing
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