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Old 06-19-2013, 04:23 PM   #2
StephN
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Join Date: Nov 2004
Location: Misty woods of WA State
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Re: CFI-400945 -Dr. Slamon - Hopeful New Drug

Thank you, Jade, for posting this one.

This is the most important part of the article to me:

With certain types of cancer, "one-size-fits-all therapy isn't going to work," said Slamon, explaining that researchers have been working to create different classes of drugs that home in on cancer cells only, leaving healthy cells alone.
"We began to look for specific therapies designed to fix what is broken instead of throwing in a bomb hoping to kill more bad than good cells," he said. "So we would target what's broken in the malignant cells. And since the normal cells don't have what's broken, they would be spared.

"And that is the whole idea of designer therapy or sharp-shooter drugs."
CFI-400945 is a new class among these designer drugs, designed to take aim at an enzyme called PLK4, which plays a critical role in cell division, especially in cancer cells.
Cells in some "genomically unstable" cancers can have scores more chromosomes than the 46 present in normal cells, and these malignant cells rely on PLK4 to be able to continue to proliferate out of control.
"So we target (the enzyme) to make sure that those cancer cells that have many chromosomes and aren't genomically stable cannot survive," said Mak.
If given FDA go-ahead for a patient trial, researchers will begin by administering the drug in about 30 volunteers with breast or ovarian cancer to see how strong a dose they can tolerate without it becoming dangerously toxic.

This is a NEW approach and I know that there are some "Sheilas" and "Chrisys" out there who are lining up to get this possible new drug.
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"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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