HER2 Support Group Forums - View Single Post - Whack-a-mole next...

donocco · 07-29-2019, 01:30 PM

The main difference with Tucatinib vs lapatanib is that Tucatinib inhibits Her 2 neu wihout inhibiting EGFR (Her-1). This means less diarrhea. It has good CNS penetration. May be worth trying.

07-29-2019, 01:30 PM	#32
donocco Senior Member Join Date: Oct 2013 Posts: 474	Re: Whack-a-mole next... The main difference with Tucatinib vs lapatanib is that Tucatinib inhibits Her 2 neu wihout inhibiting EGFR (Her-1). This means less diarrhea. It has good CNS penetration. May be worth trying.