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Becky · 03-10-2021, 06:56 PM

I am over 16 years out but got genetic testing early on. I was brca 1&2 negative. However, the years passed and they found more genes that were linked to breast and ovarian cancer. They are not linked as strongly as the brca genes. So, I got retested for 21 genes and I have a variant of unknown relevance on RAD 51D. So, they don't think it causes cancer but in time, they might find that it does. When I investigated this, known variants are strong for ovarian rather than breast. Oddly, my paternal grandmother died from ovarian cancer. I had my ovaries removed many years ago. My mother and sister both had bc as well and I made them get this full testing. They were negative all around and did not have this variant. So, maybe in 10 years I get a call this variant is something but I was told it isn't a significant gene as well. We'll see

03-10-2021, 06:56 PM	#4
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Genetic Testing I am over 16 years out but got genetic testing early on. I was brca 1&2 negative. However, the years passed and they found more genes that were linked to breast and ovarian cancer. They are not linked as strongly as the brca genes. So, I got retested for 21 genes and I have a variant of unknown relevance on RAD 51D. So, they don't think it causes cancer but in time, they might find that it does. When I investigated this, known variants are strong for ovarian rather than breast. Oddly, my paternal grandmother died from ovarian cancer. I had my ovaries removed many years ago. My mother and sister both had bc as well and I made them get this full testing. They were negative all around and did not have this variant. So, maybe in 10 years I get a call this variant is something but I was told it isn't a significant gene as well. We'll see __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"