Thread: PJ Hamel
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Old 11-21-2009, 10:23 PM   #12
hutchibk
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Re: PJ Hamel

Unregistered: if you read the responses on Dr. Love's blog about her reasons to agree with the Task Force, you will notice quite a few who ask curiously about her motivations and her company Pro-Duct Health which she sold to Cytyc in 2001 for over $150 million. I don't think she has grown horns at all, I respect her knowledge, and I reserve the right to disagree with her. I haven't accused her of anything, but Steph's musings spurred me to remember a trial she was talking about last year that she was deeply involved in, and it made me curious about potential disclosure on her part regarding her research. I have had a more focused and skeptical eye on her for two years since sitting in on her assessments of research and the ensuing discussion with other professionals on panels at SABCS the past two years. I have found her to be strong in some areas and disappointing in others.

My breast surgeon is also tremendously knowledgeable and important. He hasn't written a definitive book about breast cancer, and he's not a celebrity researcher, but he is a rock star in my book. He was interviewed the day these Task Force recommendations hit the news:

Dr. Ames Smith, chief of surgery at St. David's Hospital, says he is not changing any of his procedures based on the recommendations.

"There is clear data that shows there is a survival benefit in women that have regular screen mammography between 40 and 50," he said."In my practice, I've seen a number of women in their 40’s who have had very early cancers detected, in some cases, even before they've become invasive cancers.

"It's very similar to picking up a colon cancer before it becomes a cancer by removing a polyp," he says. "In those particular patients, there is no question they are glad those things are detected."

Dr. Smith says he also advocates women do self breast exams in conjunction with regular exams by a physician and possible mammograms.

"The thing that's dangerous about breast cancer is not just the size, but it's its biological potential to spread or metastasize, and by finding these cancers before they're invasive, it means we've found them before they've had an opportunity to metastasize, so that's a huge advantage."

Dr. Smith says he is less resistant to the task force's recommendations that mammograms be given every other year to women older than 50.

"That would be something would be easier for me to go with," he said. "I think that in general, women that are older than 50 tend to have biologically less aggressive tumors."

But he says until there is more research, he will continue to recommend annual mammograms for women 40 and older.

The Susan G. Komen for the Cure foundation, the largest private foundation in the world devoted to fighting breast cancer, is also advising caution when considering the new recommendations.

"Mammograms are the best tool we have for early detection, and right now we should stay the course and wouldn't want to impede any woman from detecting her breast cancer early," says Ramona Magid, executive director of the Austin Komen affiliate.
She says Komen is not changing its recommendations or its funding for annual mammograms.

"Even with today's guidelines, a third of the women who should be screened are not being screened due to lack of access, so Komen will continue to focus on that area," Magid said.

http://www.kvue.com/news/health/Aust...-70410852.html
__________________
Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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