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Hi Jakki,
I experienced very similar side effects as you. The rash on my face was so bad and painful, that I went down to 1000mg from 1250mg and that worked. My arms and feet began to be very painful and sore, tender so I am now down to 750mg. I have to day though that the difference between the 1000 mg and the 750 mg is neglible, whereas the dropping to 1000mg made a huge difference.
I do the 3 week on 1 week off and 3300mg of xeloda.
My onc told me that tykerb is metabolized differently by each woman and that a liver enzyme cytochrome p450 is involved with the process. He said that some women are on 250 mg up to 1500mg depending on what they can tolerate. So it is my understanding that it isn't a one size fits all dosage for tykerb.
Hope this helps.
Anne
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"Faith is the bird that feels the light when the dawn is still dark." --Rabindranath Tagore
Diagnosed Jan 2003
Bilateral Mastectomy (right prophylatic) Feb 2003
No reconstruction and no prosthesis - what you see is what you get :-)
6 rounds A/C ending August 2003
Tamoxifen til October 2004
Bone mets diagnosed October 2004
Herceptin (weekly) & Zometa (monthly) December 2004 - June 2007
Arimidex, Faslodex
Oophorectomy October 2005
Rads to left hip November 2005 - December 2005
Zometa quarterly now January 2007
Taxotere December 2005- July 2006
Tykerb (1250 mg) and Xeloda (3300mg) July 2007
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