HER2 Support Group Forums - View Single Post

Hopeful · 02-26-2007, 06:17 PM

Erin,

Thanks, I was just curious, as I am also highly ER+/PR+ Her2+ with stage 1 IDC. I can attest to the high Oncotype score (mine was 42 = 30% recurrance odds), however, I take it with a grain of salt since the Oncotype test results specify that the results are only comparable to someone with the same genetic score who was ER+ and took Tamoxifen alone. Since it has been shown that unopposed Tamoxifen (the treatment for the validation set for this test) has the potential to promote rather than inhibit Her2+ ER+ bc, I think it artificially inflates the score somewhat for those of us in that group. Since I was dx post-menopause, Tamoxifen was never a consideration, and I now take Arimidex.

I wish you the best of luck with your treatment plan, and hope that your remaining chemo treatments go smoothly for you.

Hopeful

02-26-2007, 06:17 PM	#11
Hopeful Senior Member Join Date: Aug 2006 Posts: 3,380	Erin, Thanks, I was just curious, as I am also highly ER+/PR+ Her2+ with stage 1 IDC. I can attest to the high Oncotype score (mine was 42 = 30% recurrance odds), however, I take it with a grain of salt since the Oncotype test results specify that the results are only comparable to someone with the same genetic score who was ER+ and took Tamoxifen alone. Since it has been shown that unopposed Tamoxifen (the treatment for the validation set for this test) has the potential to promote rather than inhibit Her2+ ER+ bc, I think it artificially inflates the score somewhat for those of us in that group. Since I was dx post-menopause, Tamoxifen was never a consideration, and I now take Arimidex. I wish you the best of luck with your treatment plan, and hope that your remaining chemo treatments go smoothly for you. Hopeful