Unregistered

Expression of C-myc gene protein and epidermal growth factor receptor in gastric mucosa pre- and post-Helicobacter pylori clearance

Jin-Hua Gao, Hou-Jie Liang, Wei-Wen Liu, Dian-Chun Fang and Zhen-Hua Wang

Department of Gastroenterology, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China


Abstract

AIM To investigate the effect of Helicobacter pylori infection on the expression of C-myc gene protein and epidermal growth
factor receptor (EGFR) in gastric mucosa.

METHODS The expression of C-myc gene protein and EGFR was quantitatively studied by flow cytometry and indirect immunofluorescence methods, proliferative cell nuclear antigen (PCNA) was analysed by immunochemistry method.

RESULTS The percentage of positive cells and mean fluorescence intensity of C-myc protein and EGFR were significantly increased in Hp infected mucosa and significantly decreased after Hp clearance with triple therapy. This change was similar to that in proliferative activity indicated by PCNA labeling index.

CONCLUSION The over expression of C-myc gene protein and EGFR may be the molecular basis for hyperproliferation of gastric mucosal epithelium induced by Hp infection.

Subject headingsHelicobacter pylori; gastric mucosa; C-myc gene protein; receptor, epidermal growth factor

Gao JH, Liang HJ, Liu WW, Fang DC, Wang ZH. Expression of Cmyc gene protein and epidermal growth factor receptor in gastric mucosa pre and postHelicobacter pylori clearance.Shijie Huaren Xiaohua Zazhi,1999;7(12):1018-1019


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