HER2 Support Group Forums - View Single Post - Vitamin D thread -Please use this for your Vit D info.

R.B. · 07-10-2021, 08:46 AM

Vitamin D is essential to development in utero and early years, thus it makes evolutionary sense that breast tissue would have an affinity for vitamin D, and accumulate it particularly in pregnancy. A new study considers such issues.

It is open format so the PDF can be downloaded for free.

https://cancerpreventionresearch.aac....full-text.pdf

Endlessly depressing that it is such an uphill battle to get more focus on the role of vitamin D and wider nutrients in breast cancer.

Without the nutrients they need cells cannot function optimally - that is an evolutionary inheritance imperative.

Vitamin D as a potential preventive agent for young women's breast cancer
Sarah M Bernhardt, Virgina F Borges and Pepper Schedin
DOI: 10.1158/1940-6207.CAPR-21-0114

Abstract

Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear pre-clinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating pre-clinical data to efficacy in humans. While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation. Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development. We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer.

07-10-2021, 08:46 AM	#103
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: Vitamin D thread -Please use this for your Vit D info. Vitamin D is essential to development in utero and early years, thus it makes evolutionary sense that breast tissue would have an affinity for vitamin D, and accumulate it particularly in pregnancy. A new study considers such issues. It is open format so the PDF can be downloaded for free. https://cancerpreventionresearch.aac....full-text.pdf Endlessly depressing that it is such an uphill battle to get more focus on the role of vitamin D and wider nutrients in breast cancer. Without the nutrients they need cells cannot function optimally - that is an evolutionary inheritance imperative. Vitamin D as a potential preventive agent for young women's breast cancer Sarah M Bernhardt, Virgina F Borges and Pepper Schedin DOI: 10.1158/1940-6207.CAPR-21-0114 Abstract Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear pre-clinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating pre-clinical data to efficacy in humans. While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation. Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development. We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer.