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rachelhmmd · 04-01-2012, 03:34 PM

I took tamoxifen for five years prophylactically and was diagnosed with my first mammogram after finishing the course. I am Her 2 pos/ ER pos/PR neg. When I was choosing an anti-estrogen treatment, I was still premenopausal. My onc said I could either stick with tamoxifen ( though, clearly I had lost faith in that) vs go for chemical "castration" (lupron shots) or oopherectomy to put myself into menopause So I could take an AI. I had read some stuff about tamoxifen not working as well for her 2 pos women, so I went for the oopherectomy. I'm not crazy about my "supermenopause" but I feel like it was the safest course (at least in terms of my cancer). I did not know about the association between being PR- and tamoxifen resistant, but maybe I'm living proof of that theory.

04-01-2012, 03:34 PM	#7
rachelhmmd Member Join Date: Sep 2011 Posts: 12	Re: oophorectomy and osteoporosis I took tamoxifen for five years prophylactically and was diagnosed with my first mammogram after finishing the course. I am Her 2 pos/ ER pos/PR neg. When I was choosing an anti-estrogen treatment, I was still premenopausal. My onc said I could either stick with tamoxifen ( though, clearly I had lost faith in that) vs go for chemical "castration" (lupron shots) or oopherectomy to put myself into menopause So I could take an AI. I had read some stuff about tamoxifen not working as well for her 2 pos women, so I went for the oopherectomy. I'm not crazy about my "supermenopause" but I feel like it was the safest course (at least in terms of my cancer). I did not know about the association between being PR- and tamoxifen resistant, but maybe I'm living proof of that theory.