I was on an AI (Arimidex) with Herceptin when my one bone met developed and I had some other progression.
I haven't had any of the vinca drugs. It's my understanding that I'd have to get a port for that, since it's too risky to administer them by IV. I'm certainly open to that, and to trying some other hormone treatment.
They're studying Tucatinib at the University of Colorado Hospital, where I am treated. It is an improved tyrosine kynase inhibitor (like Tykerb, which worked fairly well for me at first but didn't last), said to overcome the "cross talk" between hormone-receptor positive cells and HER2. I didn't pay much attention to it before, but now it looks pretty interesting.
https://www.sciencedaily.com/release...0111091449.htm
Amy