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Her2 Serum levels: The extracellular domain of the HER2 protein can be cleaved from the surface by metalloproteases and detected in peripheral blood and measured by enzyme linked immunosorbent assay. In GeparQuattro and GeparQuinto trials a positive association between higher sHer2 levels and a higher pCR was shown. [Witzel et al 2010, 2012]. A fall of serum Her2 levels of 20% during neoadjuvant therapy was a predictor of pCR only in the group treated with Lapitinab [Witzel et al 2012].
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Just read this and thought it might lead you to more info on serum Her2.