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janet11 · 10-01-2006, 08:27 AM

The topo ii test is still experimental, but it APPEARS that for those her2+ people needing chemo, it shows who is likely to respond to anthracycline and who might be better of on a different chemo drug.

http://www.breastcancer.org/research...in_012606.html

I'm one of the people who had the topo ii test. I'm highly HER2 positive (FISH score is 7), but for various reasons, my onc felt I should avoid anthracycline if possible. Because the topo ii test turned out negative indicating I wouldn't respond to anthracycline, I'm now on chemo with taxotere, carboplatin, and herceptin (TCH).

Janet
p.s. just corrected the name of anthracycline.... sorry if I confused anyone.

10-01-2006, 08:27 AM	#2
janet11 Senior Member Join Date: Aug 2006 Location: Rowlett, TX Posts: 138	topo ii test The topo ii test is still experimental, but it APPEARS that for those her2+ people needing chemo, it shows who is likely to respond to anthracycline and who might be better of on a different chemo drug. http://www.breastcancer.org/research...in_012606.html I'm one of the people who had the topo ii test. I'm highly HER2 positive (FISH score is 7), but for various reasons, my onc felt I should avoid anthracycline if possible. Because the topo ii test turned out negative indicating I wouldn't respond to anthracycline, I'm now on chemo with taxotere, carboplatin, and herceptin (TCH). Janet p.s. just corrected the name of anthracycline.... sorry if I confused anyone. __________________ Janet in Rowlett Texas Dx July 2006 IDC 1.8cm, ER-/PR- HER2+ (FISH 7), KI67 High (60%) grade 3, TOPO II neg Aug2006: lumpectomy, SNB (4 nodes neg), Stage 1 Jan 2007: Finished 6 cycles of TCH (Taxotere, Carboplatin, Her ceptin). Then Herceptin every 3 weeks. Feb 2007: Completed Radiation May 2007: Stopped Herceptin due to low LVEF (49%) July 2007: LVEF now 44% -- starting Coreg May 2008: Heart NORMAL! Yippee.