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I went on the HKI-272 trial in January 2007 for positive nodes in supraclavicular area. The nodes were noticeably smaller by touch within 1 week of starting the drug. I went for 5 months before nodes started to swell again and last petscan showed positive nodes in supraclav again and very small positive node in chest wall near my windpipe. Diarrhea and splitting of fingertips and toes are the only side effects I've had with the HKI but it's been quite manageable. My Onc has also told me that HKI is very similiar to Tykerb(lapatinib) but that Tykerb in combo with chemo drug capecitabine might be the next step for me.
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