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Re: Nct03368729
Yes as I realize you stated at first now, the long number is the clinical trial number. It is Niraparib and Trastuzumab (Herceptin). There are 2 different dosing schedules of Niraparib, 100mg daily for 21 days or 200mg daily for 21 days. The Herceptin seems to be the same in both groups- 8mg/KG loading dose, then 6mg/KG Hereceptin given every 3 weeks,
Zajula can cause high blood pressure, and you will probably be monitored for this. It can also cause neutropenia, thrombocytopenia and anemia. These side effects are not emphasized with Lynparza. I dont think the hypertension of Zajula has anyting to do with VEGF or its receptors but Im not sure. Blood counts are usually Routinely monitored.
I imagine the heart will be monitored due to the Herceptin. Hope this helps remove any uncertainty.
Paul
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