HER2 Support Group Forums - View Single Post - Is THIS the reason adding herceptin to chemo only improves OS by 40%?

Aussie Girl · 12-20-2014, 03:14 PM

Interesting. They would need to attach the PEGPH20 enzyme to the Her2 antibody rather than an antibody, which might be easier - provided some of the her2 antibody could get to the receptor. An antibody to the cotton candy would probably affect to much normal tissue.

First up, it would be good to have a simple test to detect the HAhigh tumours in the first place. I don't think this would be too hard to do.

Aussie Girl

12-20-2014, 03:14 PM	#10
Aussie Girl Senior Member Join Date: Jul 2013 Posts: 260	Re: Is THIS the reason adding herceptin to chemo only improves OS by 40%? Interesting. They would need to attach the PEGPH20 enzyme to the Her2 antibody rather than an antibody, which might be easier - provided some of the her2 antibody could get to the receptor. An antibody to the cotton candy would probably affect to much normal tissue. First up, it would be good to have a simple test to detect the HAhigh tumours in the first place. I don't think this would be too hard to do. Aussie Girl __________________ 31mm Infiltrating duct carcinoma Grade 3, ER/PR-, HER2+, Neg Sentinel nodes x 5 49mm field of DCIS 17 June '13: Screen detected impalpable mass, Mammogram neg, US. 25 June '13: Diagnosed after multiple biopsies and MRIs 28 June '13: Left lumpectomey 4 July '13: Left Mastectomy 12 August '13: Commenced TCH chemo Mid December '13 : TCH finished. Herceptin continuing three weekly. 4 August 2014- Herceptin infusions finished. END OF THERAPY - YAY! Last edited by Aussie Girl; 12-20-2014 at 03:19 PM.. Reason: typo