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I have been on Tykerb only since May with the same problems everyone else is experiencing - diarrhea, infected fingers and toes, acne around the nose, etc. I do have some fatigue, but hadn't thought of it as a side effect of Tykerb - just a busy schedule. The fingernail/toenail issue remains the worst problem for me - antibiotics didn't help, but I did stop getting tips on my fingernails. I now get only gel polish applied to my real nails and the infections have cleared up. I am experiencing some nail "lifting" - hopefully I won't lose the whole nail. I dropped from 5 pills/day to 3, which seems to work best for me. My tumor markers were up slightly last quarter - will have them done again next week, so we'll see.
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