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I am on Tykerb only since May, 07. Other than the diarrhea, initially I had some "hand and foot" syndrome, which disappeared. The worst side effect was and still is very sore toes (like ingrown toenails) and a few infected fingers. I have also had some hair thinning, but it seems to have stopped. The toe issues are definitely the worst problem - treat your feet very well. Doc reduced my dose to 3 pills/day, but it hasn't helped the toes.
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