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Eric,
Based on the available data curcumin is very poorly absorbed & is only present in large quantity in the guts when ingested by mouth. ( I never heard of a different mode of administration).
In trials the quantity given is in the order of 8 to 15 grams per day in divided doses. Higher doses may cause GI problems. Addition of Bioperine increases somewhat absorption but does not change much to the relatively short half life (2 to 4 hours) & Bioperine (an extract of pepper) is itself toxic in doses exceeding about 20 mg per day.
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