HER2 Support Group Forums - View Single Post - Revisiting pCR, partial response, and prognosis

AmyWeiss · 06-01-2015, 09:37 AM

Hi Lizbeth,

Thanks for posting this. I could really use your help! I was diagnosed stage IIB, HER2+, ER-,PR- , one positive node, in Dec, 2014. After receiving 6 rounds of TCHP and then a bilateral mastectomy 2 weeks ago, I just got my pathology report. Unfortunately, I did not get a pCR (crushing!) though they said my response was pretty good -- the breast tumor was gone and cancer in my node was nearly gone- 4.5 mm left. (8 other nodes removed- all clear). However, because of the cancer left on node, my doctor has suggested I go in for more chemo, AC this time, because she is worried about rogue cells in my body. I will do anything to reduce my risk of recurrence, but I'm super nervous that I didn't get pCR after what I've been reading in the research (and also about going on AC frankly). Should I request they check the Ki-67? Anything else I should be asking? What do you think about using AC at this point?
Thank you!
Amy
San Francisco

06-01-2015, 09:37 AM	#6
AmyWeiss Member Join Date: Feb 2015 Location: San Francisco, CA Posts: 6	Re: Revisiting pCR, partial response, and prognosis Hi Lizbeth, Thanks for posting this. I could really use your help! I was diagnosed stage IIB, HER2+, ER-,PR- , one positive node, in Dec, 2014. After receiving 6 rounds of TCHP and then a bilateral mastectomy 2 weeks ago, I just got my pathology report. Unfortunately, I did not get a pCR (crushing!) though they said my response was pretty good -- the breast tumor was gone and cancer in my node was nearly gone- 4.5 mm left. (8 other nodes removed- all clear). However, because of the cancer left on node, my doctor has suggested I go in for more chemo, AC this time, because she is worried about rogue cells in my body. I will do anything to reduce my risk of recurrence, but I'm super nervous that I didn't get pCR after what I've been reading in the research (and also about going on AC frankly). Should I request they check the Ki-67? Anything else I should be asking? What do you think about using AC at this point? Thank you! Amy San Francisco __________________ 47 yrs old DX 12/12/14 HER2+, ER- PR- Stage IIb, Grade 3 tumor, discovered in axillary node 12/30/14 started tx: Carboplatin, Taxotere, Herceptin and Perjeta 5/14/15 Bilateral mastectomy Pathology: partial pCR- 4.5mm left in one node, breast tumor gone, other nodes clear.