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Jean · 03-15-2007, 05:15 PM

I am a bit confused regarding the resistance to herceptin. Are there two groups of patients. Those who were resistant from the begining and the second group
being ladies who become resistant from taking herceptin? or does levels of PTEN in our boides alter and change the dyaminamics? The reason I question this is lately with the entrance of Tykerb many are mentioning adding or making treatment changes to include the Tykerb along with the herceptin.

I am just curious if there is definate information yet in regards to this?

Thanks All,
Jean

03-15-2007, 05:15 PM	#1
Jean Senior Member Join Date: Oct 2005 Location: New Jersey Posts: 3,154	Please explain.... I am a bit confused regarding the resistance to herceptin. Are there two groups of patients. Those who were resistant from the begining and the second group being ladies who become resistant from taking herceptin? or does levels of PTEN in our boides alter and change the dyaminamics? The reason I question this is lately with the entrance of Tykerb many are mentioning adding or making treatment changes to include the Tykerb along with the herceptin. I am just curious if there is definate information yet in regards to this? Thanks All, Jean __________________ Stage 1, Grade 1, 3/30/05 Lumpectomy 4/15/05 - 6MM IDC Node Neg. (Sentinel node) ER+ 90% / PR-, Her2+++ by FISH Ki-67 40% Arimidex 5/05 Radiation 32 trt, 5/30/05 Oncotype DX test 4/17/06, 31% high risk TOPO 11 neg. 4/06 Stopped Arimidex 5/06 TCH 5/06, 6 treatments Herceptin 5/06 - for 1 yr. 9/06 Completed chemo Started Femara Sept. 2006