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CoolBreeze, such wonderful news can't help but be excited and celebrate with you. I too am on Perjeta/ Herceptin combo thanks to it being recently approved for early stage Her 2+ cancers larger than 2 cm or with positive lymph nodes along with taxotere and carboplatin in the neoadjuvant setting. So much hope and encouragement posted here for us all to reach NED status. I too have had a terrific response so far. All that remains of the tumor in my breast is the tissue marker left behind from the biopsy. The positive lymph node which had reduced in size by half is stable. I am on treatment #4 of 6 planned. Taking time to rejoice with others is great medicine!! I pray you remain well for many years to come. God bless you.

__________________
HX: left breast IDC T1a node negative 1999. Lumpectomy, sentinel node biopsy, radiation therapy, 5 years of Tamoxifen, 1 year of Femara discontinued due to intolerance.
3/21/14 almost 15 years later abnormal mammogram 2 cm right breast mass deep in the breast by the chest wall, mammogram last year was normal. Ultra sound confirmed highly suspicious for malignancy.
3/26/14 needle biopsy proven IDC grade 3, ER+ PR+ Ki67 75%, Her 2 in process.
3/31/14 Consult with Breast Surgeon. Bilateral mastectomy discussed along with referral to plastic surgeon for planned surgery with reconstruction.
4/4/14 Her 2 +. My Oncologist explained that this is a new primary and unlike before in 1999 very aggressive. Surgery put on hold.
BRCA testing done. Results were negative for gene mutation.
4/7/14 PET CT for staging for possible neoadjuvant treatment. Results indicate 1.3 cm tumor and a positive lymph node.
4/9/14 lymph node biopsy. Pathology documented metastasis.
4/14/14 cardiac echo result Ejection Fraction 60%
4/16/14 Port placement
4/17/14 1st chemotherapy treatment
with Herceptin, Perjeta, taxotere and carboplatin.
4/18/14 1st treatment done yesterday with no events whatsoever!
4/23-4/25 Dreaded D hit really hard.
Daily visits to the Oncologists office for hydration and neupogen injections.
4/24/14 Started on Cipro for seriously low WBC count.
4/25/14 Results of blood count at MD office so low (ANC 0.08) I am hospitalized in isolation for neutropenic precautions. One treatment wiped out my immune system!
4/28/14 home recovering. 4/30/14 MD's new plan of treatment: reduced dose weekly taxotere, carboplatin, Herceptin with Perjeta every third week.
5/7/14 Cardiac echo > than 60% and the breast ultra sound showed 2 cm lymph node now only .5 cm. mass in breast is unable to be palpated!! treatment is a go.
5/9/14 Partial 2nd treatment, full dose Herceptin and Perjeta 1/3 dose taxotere and carboplatin.
5/13/14 lab check and fluid infusion.
5/14/14 Appointment with my Oncologist. The lab results are great and the dreaded "D" not as severe as 1st round. Then I mention that my left calf and foot are swollen and painful to the point of limping, could be the drugs but to be safe I had a venous doppler study. I have a clot in my left leg. It wasn't totally occluding the vessel and she really didn't want me in the hospital. Now I will be on Arixtra shots in my tummy till the chemo is complete sometime in August, 2014
5/16/14 continuation of 2nd treatment taxotere carboplatin only.
5/23/14 continuation of 2nd
treatment taxotere, carboplatin only
Amazingly no horrid "D" or nausea!!
5/28/14 visit with the oncologist, great news she can no longer feel a breast mass or the malignant lymph node Yippee!!
5/30/14 started 3rd chemotherapy cycle had full dose Heceptin, Perjeta ans 1/3 dose taxotere and carboplatin.
6/6/14 next dose of taxotere carboplatin for 3rd cycle
6/13/14 last dose taxotere carboplatin 3rd cycle
6/16/14 I am scheduled again for another breast ultrasound to see extent of response to chemotherapy. results will direct continued chemotherapy of directly to surgery!
6/20/14 tentative 4th chemotherapy cycle

"Zumokato Toku" is my Chemo Ninja Cancer Assassin name!

06-21-2014, 04:34 PM	#22
FLfrost Senior Member Join Date: Apr 2014 Posts: 47	Re: I'm NED CoolBreeze, such wonderful news can't help but be excited and celebrate with you. I too am on Perjeta/ Herceptin combo thanks to it being recently approved for early stage Her 2+ cancers larger than 2 cm or with positive lymph nodes along with taxotere and carboplatin in the neoadjuvant setting. So much hope and encouragement posted here for us all to reach NED status. I too have had a terrific response so far. All that remains of the tumor in my breast is the tissue marker left behind from the biopsy. The positive lymph node which had reduced in size by half is stable. I am on treatment #4 of 6 planned. Taking time to rejoice with others is great medicine!! I pray you remain well for many years to come. God bless you. __________________ HX: left breast IDC T1a node negative 1999. Lumpectomy, sentinel node biopsy, radiation therapy, 5 years of Tamoxifen, 1 year of Femara discontinued due to intolerance. 3/21/14 almost 15 years later abnormal mammogram 2 cm right breast mass deep in the breast by the chest wall, mammogram last year was normal. Ultra sound confirmed highly suspicious for malignancy. 3/26/14 needle biopsy proven IDC grade 3, ER+ PR+ Ki67 75%, Her 2 in process. 3/31/14 Consult with Breast Surgeon. Bilateral mastectomy discussed along with referral to plastic surgeon for planned surgery with reconstruction. 4/4/14 Her 2 +. My Oncologist explained that this is a new primary and unlike before in 1999 very aggressive. Surgery put on hold. BRCA testing done. Results were negative for gene mutation. 4/7/14 PET CT for staging for possible neoadjuvant treatment. Results indicate 1.3 cm tumor and a positive lymph node. 4/9/14 lymph node biopsy. Pathology documented metastasis. 4/14/14 cardiac echo result Ejection Fraction 60% 4/16/14 Port placement 4/17/14 1st chemotherapy treatment with Herceptin, Perjeta, taxotere and carboplatin. 4/18/14 1st treatment done yesterday with no events whatsoever! 4/23-4/25 Dreaded D hit really hard. Daily visits to the Oncologists office for hydration and neupogen injections. 4/24/14 Started on Cipro for seriously low WBC count. 4/25/14 Results of blood count at MD office so low (ANC 0.08) I am hospitalized in isolation for neutropenic precautions. One treatment wiped out my immune system! 4/28/14 home recovering. 4/30/14 MD's new plan of treatment: reduced dose weekly taxotere, carboplatin, Herceptin with Perjeta every third week. 5/7/14 Cardiac echo > than 60% and the breast ultra sound showed 2 cm lymph node now only .5 cm. mass in breast is unable to be palpated!! treatment is a go. 5/9/14 Partial 2nd treatment, full dose Herceptin and Perjeta 1/3 dose taxotere and carboplatin. 5/13/14 lab check and fluid infusion. 5/14/14 Appointment with my Oncologist. The lab results are great and the dreaded "D" not as severe as 1st round. Then I mention that my left calf and foot are swollen and painful to the point of limping, could be the drugs but to be safe I had a venous doppler study. I have a clot in my left leg. It wasn't totally occluding the vessel and she really didn't want me in the hospital. Now I will be on Arixtra shots in my tummy till the chemo is complete sometime in August, 2014 5/16/14 continuation of 2nd treatment taxotere carboplatin only. 5/23/14 continuation of 2nd treatment taxotere, carboplatin only Amazingly no horrid "D" or nausea!! 5/28/14 visit with the oncologist, great news she can no longer feel a breast mass or the malignant lymph node Yippee!! 5/30/14 started 3rd chemotherapy cycle had full dose Heceptin, Perjeta ans 1/3 dose taxotere and carboplatin. 6/6/14 next dose of taxotere carboplatin for 3rd cycle 6/13/14 last dose taxotere carboplatin 3rd cycle 6/16/14 I am scheduled again for another breast ultrasound to see extent of response to chemotherapy. results will direct continued chemotherapy of directly to surgery! 6/20/14 tentative 4th chemotherapy cycle "Zumokato Toku" is my Chemo Ninja Cancer Assassin name!