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Old 09-20-2012, 02:18 AM   #36
michka
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Join Date: Feb 2007
Location: Paris, France
Posts: 858
Re: TDM-1 side effects

Thank you Fern for sharing. I had started a thread asking if anybody had chest pain and breathing problems with TDM1 and knew the reasons. 2 or 3 persons reported chest pain and one lung inflammation. I still have the same problem and my heart is fine. One Dr even told me to take a tranquilizer. Did you ever feel like punching a Dr in the nose? Well I did. :-) . ...but I just didn't answer because he is a nice man...(and I don't "punch").
I will have the onc really look at my next scans to be sure there is no lung inflammation. I had a first indication through Barbara H who reported she had to stop and now through your post. I ergo know what to watch. I only had 8 rounds and hope I can continue a long time.
Otherwise my side effects are nausea the first week, fatigue, neuropathy that wakes up at each cycle (induced by Taxol), spots and big pimples on my face the second week, very very dry eyes nose and mouth. Some rounds are better (or worse) then others without being able to know why. I am less fatigued than in the first cycles. I also had pains during my first rounds but not anymore. The very big fatigue and the pains in the beginning maybe came from the destruction of cancer cells or it is just my body that adjusted. But I prefer the first explanation!
Michka
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex

12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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