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Old 06-24-2011, 02:28 PM   #7
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
Re: TDM-1 side effects

Hi fern,

I sent you an email, but adding some comments here re the milk thistle.

I had pretty severe elevation of LFT's and practically lived on a liver detox diet for months - lots of carrot salad, beet juice, green soup/juice and milk thistle. Of course I also ate other stuff

My doctor had no problem with these, including the supplements. I also took Olive Leaf and Coq10 regularly and bits and pieces of other supplements during the 3 years I was on TDM-1. The only one they nixed was Curcumin. But I always make sure they know what I'm taking, because of the potential interactions with the therapy.

Brenda is right, the flu-y side effects got less intense for me, too.

Karen, I haven't heard anything about the FDA reconsidering the TDM1 early approval - it might just be wishful thinking, but I hope you're right!
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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