One of the threads in your attachment.
Leptin increasing the oncogenic potential of erbB2 (HER 2).
From what I read high leptin levels are found in those with high body fat content.
Is it acting in concert or independently of oestrogen?
Interesting.
RB
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
1: FEBS Lett. 2004 May 7;565(1-3):139-42. Related Articles, Links
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Transactivation of erbB2 by short and long isoforms of leptin receptors.
Eisenberg A, Biener E, Charlier M, Krishnan RV, Djiane J, Herman B, Gertler A.
http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum
Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel.
We generated kinase-positive and kinase-negative erbB2 tagged with YFP and the long form of leptin receptor (LEPRb) tagged with CFP. Both were as active as their untagged analogs. Both short and long isoforms of leptin receptor phosphorylated and thereby activated erbB2 upon leptin binding and enhanced MAPK activity. Our results unveil a novel route by which leptin may provoke erbB2's phosphorylation and thus enhance its oncogenic potential independently of HER family ligands or its overexpression. Using FRET technology in living cells, we found no evidence of complex formation between erbB2 and prolactin or leptin receptors, indicating that the transactivation occurs through an indirect interaction.
PMID: 15135067 [PubMed - indexed for MEDLINE]