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Re: Enhertu
Such a coincident, my wife has bone met in the exact same 3 areas as DonnaH, she also has lung mets. Next week would be our 5 months on Enhertu, tumor marker has been coming down fast the first 3 months, but slowing downward trend now. At best scans show stable bone (bone environment protects tumor), perhaps slight reduction in lung nodules.
The two supporting drugs, Palonosetron and Dexamethasone, cause additional problems. Dexamethasone causes jittery/hyper then insomnia the first 2-3 days after administration, followed by tiredness from lack of sleep. Palonosetron causes severe dizziness and tiredness. The two combines to cause her not able to function essentially for 2/3 of the days in between 3-week cycle.
The main purpose of Dexamethasone (a steroid) is to prevent allergic reaction and nausea. If you have no reaction after the first 2-3 cycles, discuss with your oncologist of reducing dexamethasone then eliminate it, if no problem with reduction. We started reduction Dexamethasone by half then eliminate it. Palonosetron main purpose is to prevent nausea, we use the same reduction method and eliminate it too. She is doing much better now without the two supporting drugs. Incidentally she is also on Zarzio, an immune system booster due to perpetually low count from all the years of continuous treatment.
Nguyen
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