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Becky · 04-09-2007, 05:14 PM

Dear Steph

It is such a hard call as less than 10% (in many references) is called negative. Perhaps you should have your slides read elsewhere. For example, less than 10% could be the lowest reading on that criteria at the lab it was done.

For example, 9 is less than 10 and 1 or 0 is also less than 10 but if less than 10 - is it 0 in your case?

In almost ALL cases less than 5% is negative (which is the reading for my PR and my onc considers this negative because it is the lowest reading at the pathology lab where my slides were first sent to). I sent them to Sloane Kettering for a re-read and got PR negative status of less than 1% (since I suppose that is their lowest reading)

Tamoxifen tends to not work well if you are Her2+ in general and works even less so if you are not highly ER and PR positive.

04-09-2007, 05:14 PM	#10
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Dear Steph It is such a hard call as less than 10% (in many references) is called negative. Perhaps you should have your slides read elsewhere. For example, less than 10% could be the lowest reading on that criteria at the lab it was done. For example, 9 is less than 10 and 1 or 0 is also less than 10 but if less than 10 - is it 0 in your case? In almost ALL cases less than 5% is negative (which is the reading for my PR and my onc considers this negative because it is the lowest reading at the pathology lab where my slides were first sent to). I sent them to Sloane Kettering for a re-read and got PR negative status of less than 1% (since I suppose that is their lowest reading) Tamoxifen tends to not work well if you are Her2+ in general and works even less so if you are not highly ER and PR positive. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"